Surprisingly, opioids may increase the risk of chronic pain

After surgery, opioids, such as morphine, are routinely used to control pain. However, according to a new study, medications can actually increase the likelihood of experiencing chronic pain.
Opioid drugs and the word
New study reveals a new concern about the use of opioids.
Opioids are good news. The “opium epidemic” in the United States destroys life from coast to coast.

More than 100 people die from an opiate overdose every day in the United States.

Despite the horrors of addiction, one aspect of opioid use that is rarely questioned is how effective they are in achieving their primary function: to soothe pain.

After being used in one form or another for thousands of years, opioids multiply the pain in submission, making the patient feel more comfortable. The latest study, conducted at the University of Colorado at Boulder, made this firmly on its head.

“There is another dark side to opiates that many people doubt,” says lead researcher Professor Linda Watkins of the Department of Psychology and Neurology.

In this case, not the additional problems mentioned by Professor Watkins. Ironically, opioids can prolong pain after surgery. The results were recently published in Anesthesia and Analgesia.

Examine the pain of stock exchanges and opiates
For the study, Professor Watkins and his colleague Peter Gray of the MD Anderson Cancer Center in Houston, Texas, performed a laparotomy on male rats. This procedure involves incision through the abdominal wall to reach the inside of the abdomen, and this is done to tens of thousands of American people each year.

“Opioids are really effective in relieving acute pain, but little research is done to see what they do in weeks or months after they are removed.”

Peter Grace
After surgery, one group of mice received the equivalent of a moderate dose of morphine for the next seven days, while another group received morphine for 8 days and the dose was excluded on day 10.

Another group of morphine was administered for 10 days, and then the treatment stopped abruptly. The last group received injections of saline instead of morphine as the control group.

In another trial, a group of mice received a cycle of morphine for 7 days that ended one week before surgery.

Before the morphine system was started, once finished, the sensitivity of the rats to the touch was measured, as was the activity of the genes related to spinal cord inflammation.

Compared to mice that received saline, those who received postoperative pain with morphine were tolerated for more than 3 additional weeks. Also, the longer the morphine is delivered, the worse the pain in the mice.

The study also found that the decrease in the dose of morphine was not different. As Grace explains: “This tells us that this is not a phenomenon related to the withdrawal of opium, which we know can cause pain.

How can morphine relieve pain after surgery?
The next question, of course, is what drives this obvious effect. Professor Watkins calls it a “one hit” result in glial cells.

In the brain, glial cells are more numerous than neurons. It protects and supports neurons, and as part of their protective function, directs the immune response to the brain, including inflammation.

The first “heartbeat” occurs when surgery activates future 4 as (TLR4) in the glial cells. Professor Watkins describes this as “not me, it’s not true, it’s not right”. Receptors Help regulate the inflammatory response. This first blow drives them to work when the second blow occurs.

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